Is sclerostin a reliable biomarker for disease severity? Evaluation of sclerostin levels in the serum and gingival crevicular fluid of rheumatoid arthritis patients with periodontitis: A case‒controlled study

Hussien, Aya Ali; B.Attia, Omina; Mohammed, Ebtehal; Abdal Wahab, Mahetab

doi:10.21608/asdj.2025.341604.1703

Is sclerostin a reliable biomarker for disease severity? Evaluation of sclerostin levels in the serum and gingival crevicular fluid of rheumatoid arthritis patients with periodontitis: A case‒controlled study

Document Type : Original articles

Authors

¹ oral medicine and periodontology- Faculty of Dentistry- Egyptian Russian University- Cairo- Egypt

² Internal Medicine Department, Rheumatology Division, Faculty of Medicine, Ain Shams University, Cairo, Egypt

³ Oral medicine and Periodontology, Faculty of Dentistry, Beni-Suef University.

⁴ 1. Oral Medicine ,Periodontology And Oral Diagnosis Faculty Of Dentistry .Ain Shams University. 2. Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry- Egyptian Russian University- Cairo- Egypt

10.21608/asdj.2025.341604.1703

Abstract

Aim: In the present study, we selected Rheumatoid arthritis (RA) with stage III periodontitis as both diseases are characterized by bone loss to evaluate the reliability of sclerostin, as a biomarker for disease severity, in both the serum and gingival crevicular fluid (GCF).
Materials and methods: A total of 36 participants were included in this study, with 12 participants in each group: patients with RA with stage III periodontitis, healthy patients with stage III periodontitis and healthy controls. Serum samples and GCF samples were collected from the pocket with greatest clinical attachment loss in periodontitis patients and the gingival sulcus of healthy controls. The sclerostin concentration in the samples was assessed by enzyme-linked immune assay (ELIZA).
Results: There was no significant difference between the serum or GCF sclerostin levels of the three groups. Additionally, there was no association between the serum and GCF sclerostin levels among or within the groups.
Conclusion: Among the limitations of the present study, sclerostin did not reflect the severity of periodontitis or RA. However, it may reflect the disease activity with further studies are recommended.

Keywords

Main Subjects