Castor oil effects on bone healing defect in rats: An experimental study

Document Type : Consort randomized clinical trials (RCT)

Author

college of dentistry university of Baghdad

10.21608/asdj.2024.326544.1561

Abstract

Aim: evaluation the effect of castor oil on bone healing in rats.
Materials and methods: study done in 24 rats with two-bone defect in each rats so 48 bone defect studied in this research. General anesthesia given intramuscularly to all rats. Make an incision in the right and left femur, muscles reflection and expose the bone. Using the round bur for the hand piece of microingen, make a hole about 3 mm deep and 2 mm wide, with continues washing. Holes in the right side left without treatment while holes in the left side treated with 0.5 ml castor oil. After that, we sew the muscle and skin and randomly dividing the rats into two healing periods: the second and sixth weeks. At each healing period twelve rats (24 holes) used. After giving general anesthesia, exposed the defect bone and cutting, then putting in formalin after that doing the processing procedure to get a tissue with Hematoxylin and Eosin stain. The slide examined under light microscope and evaluated histologically.
Results: Castor oil group recorded higher mean value in all parameter except bone marrow area than the control group at second week. At 6th week, the experimental group recorded higher mean value in all parameter except osteoclasts account and bone marrow area than control group.
Conclusion: castor oil accelerated bone healing in rats.
 

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