Document Type : Original articles
Authors
1
Researcher assistant ,Endodontic Department , national research center. Cairo ,Egypt
2
Faculty of Oral and Dental Medicine, Head of endodontic department Ain Shams University
3
Dept. of Surgery, Anesthesiology & Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt Faculty of Dentistry, Galala University, New Galala city, Suez, Egypt
4
Professor, Department of Endodontics, Faculty of Dentistry, The British University in Egypt (BUE), El Sherouk City, Egypt. Professor, Restorative and Dental Materials Department, National Research Centre, Giza, Egypt.
5
Department: Pharmaceutics and Drug Manufacturing. faulty of pharmacy, Modern Technology and Information University (MTI).
10.21608/asdj.2025.342662.1709
Abstract
Aim: This study presents the synthesis, material characterization, and evaluation of the antimicrobial activity of antibiotic-loaded scaffolds.
Materials and methods: Metronidazole (MID) or Ciprofloxacin (CIP) was incorporated into a polylactic acid (PLA) polymer solution at a concentration of 25 wt.% and then processed into Fibers. Neat PLA nanofibers were used as controls. Characterization techniques, including scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), degradation tests, and drug release assessments, were employed. The antimicrobial properties were tested against Porphyromonasgingivalis (Pg) and Enterococcus faecalis (Ef).
Results: SEM imaging showed Fibers with submicron diameters, and FTIR confirmed the successful incorporation of the antibiotics. Data analysis demonstrated a gradual and sustained release of the drugs from the scaffolds over 48 hours. Antimicrobial activity was confirmed via agar diffusion assays, showing efficacy against the tested bacteria.
Conclusion: Antibiotic-loaded electrospun PLA scaffolds could serve as biologically safe antimicrobial drug delivery systems for use in regenerative endodontics.
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