Document Type : Consort randomized clinical trials (RCT)
Authors
1
Master of Oral Medicine and Diagnosis Faculty of Dentistry, Ain Shams University, Cairo, Egypt
2
Associate Professor of Oral medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
3
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
4
Professor of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt and Dean of Faculty of Oral and Dental Medicine, Nahda University in Beni Suef, Egypt.
Abstract
Aim: To assess the effect of zinc supplements in management of symptomatic benign migratory glossitis patients as a primary outcome and to evaluate levels of salivary zinc before and after treatment as a secondary outcome.
Materials and Methods: A randomized controlled clinical and biochemical study was carried out on 48 patients diagnosed with geographic tongue. Patients were divided equally into two groups; the study group received zinc supplements along with a zinc-rich diet for one month, while the control group was given only a zinc-rich diet for the same duration. Clinical parameters including the size of red atrophic areas (atrophic area length, atrophic area width), and visual analogue scale pain score. Both parameters were recorded at baseline, after one month of treatment and after one month later without treatment. Salivary samples were collected from both groups for biochemical analysis (measuring zinc levels) at baseline and one month after treatment.
Results: Reduction in values of atrophic area length (9.88±5.51), atrophic area width (6.5±4.26) in study group compared to (10.88±2.31), (7.38±2.14) respectively in control group, significantly higher median values of visual analogue scale pain score in control group (5.5), in comparison to study group (3.5), (p=0.004), as well after one month of treatment, the study group exhibited a significantly higher salivary zinc mean value compared to the control group (p=0.045).
Conclusion: Low dose of zinc sulphate has a significant therapeutic effect on the relief of subjective symptoms in patients with BMG.
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