Efficacy of Aleo Vera in Prevention and Treatment of Chemotherapy-induced Oral Mucositis in A group of Egyptian Children with Acute Leukemia: Randomized Controlled Trial.

Document Type : Consort randomized clinical trials (RCT)

Authors

1 37FV+PH3، شارع منظمة الوحدة الافريقية، كوبري القبة، الوايلى، محافظة القاهرة‬ 4393005

2 Pediatric dentistry and dental public health, Faculty of dentistry, Ain shams university

3 Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Abstract

Aim: The aim of the study was to evaluate the efficacy of Aloe Vera (AV) in prevention and treatment of chemotherapy-induced oral mucositis(CIOM) in a group of Egyptian children suffering from acute leukemia in terms of appearance and severity.
 Materials and Methods: A randomized controlled trial  (RCT) was conducted over a period of 2 months at Nasser Institute Hospital for Research and Treatment (NIH). The study included 40 patients undergoing treatment for acute lymphoblastic leukemia (ALL). They were assigned into two groups; in the intervention group (20 patients) applied 70% AV gel topically three times daily, starting three days before chemotherapy and over a period of two months. While, the control group did not receive this treatment; instead, they used routine mouthwashes prescribed by their physicians, including chlorhexidine or  nystatin.
 Results: At baseline, all the cases in both groups were free from oral mucositis (OM) .After 2 months, a significantly higher percentage of cases in the control group (85%) were affected in comparison to the study  group (15%) (p<0.001).  For the study group, the mean onset was 19 days , while for the control group, the mean was 13 days. All cases with OM in study group presented with lower grades of severity than the control group.
Conclusion: AV had a significant effect in preventing CIOM and notably reduces both the duration and severity of symptoms compared to the control group. These findings suggest that AV gel could be a valuable therapeutic option for managing CIOM.

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