Formulation and evaluation of anti-inflammatory and antioxidant activities of Glycyrrhiza glabra (licorice) and Triphala based gum paint

Document Type : Original articles

Authors

1 Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu

2 Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu

Abstract

Aim: This study aimed to develop a herbal gum paint with potential anti-inflammatory and antioxidant benefits for treating oral conditions such as aphthous ulcers and periodontal diseases. By utilizing natural herbal extracts, this gum paint could provide a safer, possibly more effective alternative to conventional treatments.
Materials and Methods :The gum paint was formulated using concentrated extracts of Triphala and Glycyrrhiza glabra. Triphala, a blend of three fruits, and Glycyrrhiza glabra, known for its medicinal properties, were selected for their anti-inflammatory and antioxidant effects. Anti-inflammatory activity was assessed with the Bovine Serum Albumin Denaturation Assay, while antioxidant activity was measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) Assay.
Results: The gum paint demonstrated promising anti-inflammatory and antioxidant properties. At a concentration of 50 μL, it showed the highest anti-inflammatory activity, comparable to the control group. The antioxidant activity was also optimal at this concentration. These findings suggest that the gum paint effectively reduces inflammation and oxidative stress, which are important in oral health conditions.
Conclusion : The herbal gum paint shows significant potential as an alternative to conventional treatments for oral health issues. By leveraging the combined effects of Triphala and Glycyrrhiza glabra, the formulation offers notable anti-inflammatory and antioxidant benefits. Further research and clinical trials are needed to confirm its efficacy and safety for broader clinical application.
 

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