Comparative evaluation of clinicopathological features and Cytokeratin profile of ‘so-called inflammatory’ and development dentigerous cysts

Sinha, Pranam; PANDIAR, DEEPAK; Krishnan, Reshma Poothakulath

doi:10.21608/asdj.2025.334189.1620

Comparative evaluation of clinicopathological features and Cytokeratin profile of ‘so-called inflammatory’ and development dentigerous cysts

Document Type : Original articles

Authors

¹ Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu

² Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

10.21608/asdj.2025.334189.1620

Abstract

Aim: To compare the clinicopathological and immunohistochemical features of ‘so-called inflammatory’ and developmental dentigerous cysts (DC) to elucidate the histogenesis of these lesions.
Materials and methods: The present study included 12 cases of inflammatory DC, which were compared with eleven cases of developmental DC and 10 human tooth germs after obtaining clearance from the institutional ethical board. The data were obtained from the archives, and all 33 blocks were subjected to immunohistochemistry with CK8, CK10, CK14 and CK18.
Results: No significant difference was noted in any of the clinical or radiological features between the two study groups. The overall mean age of 23 cases was 15.95 years. The mean age of cases in Group I and Group II was 15.5 years and 16.45 years respectively. Histologically, group I showed radicular cyst-like epithelia with 2-6 layered thickness with rete-peg formation; the epithelium was thin non-keratinized in the group II. The tooth germs expressed CK8 and CK14 with no CK10 and CK18 immunoexpression. Both study groups have strongly expressed CK8 and 14. While CK 18 was confined to the surface layer. The CK10 showed weak expression in the superficial layers in some cases.
Conclusion: The results of the present study showed that the ‘inflammatory’ and developmental dentigerous cysts show similar clinical and immunohistochemical profiles. The presence of an inflammatory stimulus, results in hyperplasia of the epithelium and a distinction between these two may not be required. The results of the present study need confirmation with studies with larger sample size.

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