Associations Between Body Mass Index, HbA1c Levels, Salivary MMP-9 Concentration, and Periodontal Parameters in Patients with and without Periodontitis

Document Type : Original articles

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college of dentistry, University of Baghdad

10.21608/asdj.2024.333244.1615

Abstract

Aim: Correlation among BMI, HBA1c, salivary MMP9, and periodontal parameters in patients with and without periodontitis.
Materials and Methods: 150 people participated in the case-control study and were divided into 75 patients with periodontitis (study group) and 75 with healthy periodontium (control group). Unstimulated saliva and serum samples were obtained from each participant before the clinical periodontal parameters’ measurement involving PLI, BOP, PPD, and CAL, With age and BMI demographic factors. Saliva concentration of MMP9 and serum HBA1c were measured for each participant.
Results: The periodontitis group showed higher levels of salivary MMP9, serum HBA1c, and BMI measurement than the control group, with significant differences (P value <0.5). A positive significant correlation was found between MMP9 with PPD and CAL, also between BMI and PPD in the study group while for the control group, a positive significant correlation between MMP9 with BMI (P value <0.5)
Conclusion: The study shows a correlation between elevated levels of MMP9, HBA1c, and BMI with periodontitis. The complicated interaction between these factors in the onset and progression of periodontal disease is suggested by the positive correlations shown between BMI and PPD, as well as between MMP9 and PPD/CAL. More research is required to comprehend the underlying mechanisms completely and investigate potential therapeutic strategies that target these characteristics.

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