Stem Cells-Derived Exosomes Versus Injectable-Platelet Rich Fibrin effect on Irradiated Submandibular Salivary Glands

Document Type : Original articles

Authors

1 Oral Biology department faculty of dentistry Ain shams university

2 Oral Biology department, faculty of dentistry, Ain shams university

3 Oral Biology department , faculty of dentistry , Ain shams university

10.21608/asdj.2025.343693.1717

Abstract

Aim: This study aimed to compare the ameliorative potentials of Injectable-Platelet Rich Fibrin (I-PRF) and Bone marrow mesenchymal stem cells (BM-MSCs) derived exosomes on irradiated rat submandibular salivary glands (SMGs).
Materials and Methods: Forty-nine male albino rats had been divided into 4 main groups (12 rats each) and one rat had been used as doner. Group I served as –ve control while Group II had been exposed to gamma irradiation (single dose of 6 Gy) and the other two groups were injected 24 h post-radiation with a single dose of I-PRF (Group III), exosomes (Group IV). SMG regeneration was assessed in terms of histological changes, ultra-structural changes and TGF- β1 gene expression.
Results: The results showed that compared to the irradiated group all treated groups showed successful regeneration.  Our results prove that using I-PRF and Exosomes could be promising in decreasing irradiation side effects on SMG.
Conclusion:   BM-MSCs derived exosomes and IPRF had a role in regeneration of irradiated SMG. Our results demonstrated that using IPRF had ameliorative effect in regeneration of irradiated SMG but for a short-term duration unlike exosomes that mediate a better regenerative effect on long term duration.

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