Correlation of CD73 Immunohistochemical Expression and Angiogenesis in Benign and Malignant Salivary Gland Tumors

Document Type : Original articles

Authors

1 Demonstrator of Oral Pathology Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

2 Assistant Professor of Oral Pathology Department, Faculty Of Dentistry, Ain Shams University, Cairo, Egypt.

3 Assistant Professor of Oral Pathology Department, Faculty of Dentistry Ain Shams University

10.21608/asdj.2024.319868.1504

Abstract

Aim: to detect immunohistochemically the expression of CD73 and vascular endothelial receptor-2 (VEGFR-2) in both benign and malignant salivary gland neoplasms and to detect the correlation between CD73 and VEGFR-2 if present.
Materials and methods: The current study consisted of forty specimens of 8 cases normal control group of salivary gland tissue, benign salivary gland (SG) neoplasms including pleomorphic adenoma (PA) and warthin’s tumor (WT) and malignant group including mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ADC), 8 cases for each subgroup. Immunohistochemical staining with anti-CD73 and anti-VEGFR-2 primary antibodies was performed. Immunopositivity area fraction was measured by image analysis software followed by statistical analysis using Studen’s t-test (unpaired) and ANOVA followed by Tukey.  Pearson’s correlation was used to correlate between CD73 &VEGFR-2.
Results: Higher expression of CD73 and VEGFR-2 was observed in malignant SG neoplasms than benign neoplasms. In addition, benign neoplasms showed higher expression than normal control group. A significant correlation between CD73 and VEGFR-2 was observed indicating their role as a promising prognostic marker.
Conclusion: The high expression of CD73 and VEGFR-2 indicates poor prognosis and might be used as a reliable prognostic marker in SG neoplasms and there is a direct correlation between them.

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